ADHD burden
ADHD can be a lot to handle
Along with ADHD diagnostic symptoms* of inattention and hyperactivity/impulsivity, associated features—such as emotional dysregulation and executive dysfunction—may also impact patients.1,2 When these challenges stack up, especially alongside comorbidities, patients may be left with unaddressed needs.
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See how these ADHD challenges can stack up
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59% of treated adults with ADHD still report difficulties in sustaining attention and concentration.1

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Even with treatment, many patients with ADHD continue[br-d] to experience some[br-d] symptoms, which can include emotional dysregulation (45%) and executive dysfunction (37%).1,3

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Up to 64% of children and up to 80% of adults with ADHD have at least 1 comorbid disorder, including anxiety.4-7

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*Diagnostic symptoms are included in the DSM-5-TR diagnostic criteria. Associated features are separate from diagnostic symptoms but support a diagnosis of ADHD and can exacerbate the impairment patients already face with ADHD.
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THE SCIENCE OF ADHD
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Multiple neurotransmitters[br-m] may play a role in[br-d] ADHD symptoms4,8,9

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Treat adhd differently
Discover the trio in action
The interplay among these 3 neurotransmitters—norepinephrine, dopamine, serotonin—[br-d]may be responsible for the distinct mix of diagnostic symptoms and associated[br-d] features in each patient.4,8,9
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See Simtriyo in Action
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REFERENCES
  1. Brown TE, et al. The patient perspective: unmet treatment needs in adults with attention-deficit/hyperactivity disorder. Prim Care[br-m] Companion CNS Disord. 2019;21(3):18m02397.
  2. American Psychiatric Association. Diagnostic[br-m] and Statistical Manual of Mental Disorders. Fifth[br-m]Edition, Text Revision. DSM-5-TR™. American[br] Psychiatric Publishing; 2022.
  3. Schein J, et al. Symptoms associated with ADHD/treatment-related adverse side effects[br-m]and their impact on quality of life and work productivity[br-d] in adults with ADHD. Curr Med Res[br-m] Opin. 2023;39(1):149-159.
  4. Shaw P, et al. Emotion dysregulation in[br-m]attention deficit hyperactivity disorder. Am J Psychiatry. 2014;171(3):276-293.
  5. Kessler RC, et al. The prevalence and correlates[br-m] of adult ADHD in the United States: results[br-m] from the national comorbidity survey[br-m] replication. Am J Psychiatry.[br-m] 2006;163(5):716-23.
  6. Danielson ML, et al. Prevalence of parent-[br-m]reported ADHD diagnosis and associated[br-m] treatment among U.S. children and[br-m] adolescents, 2016. J Clin Child Adolesc Psychol. 2018;47(2):199-212.
  7. Katzman MA, et al. Adult ADHD and comorbid disorders: clinical implications of a dimensional approach. BMC Psychiatry. 2017;17(1):302.
  8. Faraone SV, Larsson H. Genetics of attention[br-m] deficit hyperactivity disorder. Mol Psychiatry. 2019;24(4):562-575.
  9. da Silva BS, et al. An overview on neurobiology[br-m] and therapeutics of attention‑deficit/[br-m]hyperactivity disorder. Discov Ment Health. 2023;3(1):2.
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